Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Cell surface SARS-CoV-2 nucleocapsid protein modulates innate and adaptive immunity세포 표면 SARS-CoV-2 뉴클레오캡시드 단백질은 선천성 및 후천성 면역을 조절합니다Article Published on 2022-08-052022-09-11 Journal: Science Advances [Category] SARS, 변종, 치료기술, 치료법, 치료제, [키워드] activate adaptive antibody antigenicity bind Cell cell surface cells chemokine chemokines chemotaxis Combination conserved CoVs cross-reactive cytosol detect electrostatic heparan sulfate heparin high affinity high-affinity binding human CoVs immune cells Immunity induce infected cells inhibited Innate immune cells Innate immunity leukocyte leukocytes live cells MERS-CoV modulate neighboring cell neighboring cells nucleocapsid protein Protein released SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-infected cell SARS-CoV-2-infected cells sequestering Strains sulfate sulfated T cell T cell responses transfected cell Vaccine zoonotic [DOI] 10.1126/sciadv.abp9770 PMC 바로가기 [Article Type] Article
The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2단량체 C 반응성 단백질의 콜레스테롤 결합 서열은 SARS-CoV-2 스파이크 수용체 결합 도메인에 결합하고 안지오텐신 전환 효소 2와의 상호 작용을 차단합니다Article Published on 2022-07-082022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids angiotensin bind binding block C-reactive protein C-reactive protein (CRP CBS Cell cell surface Characteristics cholesterol cholesterol-binding sequence clinical coronavirus COVID-19 pathogenesis Critical CRP CRP level CRP levels diagnostic domain experiment functional highlight human Angiotensin-converting enzyme Inflammation inhibit Innate immunity Interaction involved marker monomeric monomeric C-reactive protein motif mutant overexpressed Pathogenesis patients with COVID-19 Pattern recognition pattern recognition receptor pattern recognition receptor. peptide provide RBD receptor Receptor-binding domain reduced SARS-CoV-2 SARS-CoV-2 Spike RBD sequence severe acute respiratory syndrome Coronavirus spike Spike protein surface plasmon surface plasmon resonance the SARS-CoV-2 the spike protein therapeutic virus [DOI] 10.3389/fimmu.2022.918731 PMC 바로가기 [Article Type] Article
The Impact of D614G Mutation of SARS-COV-2 on the Efficacy of Anti-viral Drugs: A Comparative Molecular Docking and Molecular Dynamics StudySARS-COV-2의 D614G 돌연변이가 항바이러스제의 효능에 미치는 영향: 분자 도킹 및 분자 역학 비교 연구Article Published on 2022-07-062022-09-11 Journal: Current microbiology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] affected Analysis antiviral drug antiviral drugs binding affinities binding affinity Cell cell surface Characteristics Comparative Coronaviruses cytarabine D614G D614G variant docking method docking result docking results drug Dynamics evaluated exhibited Impact In-vitro Interaction molecular docking molecular dynamics Molecular dynamics simulation mutated Mutation parameter rate of infection receptor reliability reported ribavirin Spike protein the binding affinity the RBD the spike protein was performed [DOI] 10.1007/s00284-022-02921-6 PMC 바로가기 [Article Type] Article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species Reactive oxygen species. reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
The life cycle and enigmatic egress of coronaviruses코로나바이러스의 수명 주기와 불가사의한 탈출Review Published on 2022-06-012022-09-11 Journal: Molecular microbiology [Category] COVID19(2023년), SARS, 치료법, [키워드] adopted alternative route causative agent Cell cell surface cellular Consensus coronavirus CoV CoV infection CoV replication COVID-19 pandemic CoVs drugs Endoplasmic reticulum expression Extracellular genome replication genomic RNA Golgi Golgi apparatus host cell host cells Interference life cycle lumen membrane envelope mobilization nucleocapsid nucleocapsid protein Nucleocapsid proteins pandemic pathway progeny promote Protein rab1 rab11 respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shown situation the Golgi apparatus the intermediate compartment (IC) the recycling endosome (RE). therapeutic virion assembly virus virus [DOI] 10.1111/mmi.14907 PMC 바로가기 [Article Type] Review
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology Virology. virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 PatientsCOVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19 [DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology